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Structural Heart June 30, 2025
Foldax’s TRIA Mitral Valve Impresses at NYV June 30, 2025
The valve replacement space keeps adding contenders, and Foldax’s polymer-based TRIA Mitral Valve replacement showed compelling one-year results in its India Clinical Trial presented at New York Valves 2025, suggesting we could soon have an alternative to bovine tissue valves. Researchers tested the new surgical TRIA polymer valve on 67 patients (aged 19 to 67) […]
Population Health June 26, 2025
Save the Planet to Save Our Hearts (From Microplastics) June 26, 2025
We’ve all cut down on plastic straws to save the sea turtles, but what about ourselves? A recent AHA study suggests there could be a link between ocean microplastic levels and cardiovascular disease in U.S. coastal counties, adding to a concerning trend of microplastics and CV risk. Researchers analyzed counties near waters with high and […]
Surgeries & Interventions June 23, 2025
Edwards’ Evoque Might Have More Adverse Events Than Previously Known June 23, 2025
Over a year after becoming the first FDA-approved transcatheter tricuspid valve replacement system, a new JACC study suggests Edwards Lifesciences’ Evoque TTVR system might have some risks that regulators hadn’t previously considered. Searching for more answers about Evoque’s real world risks, researchers pulled data from the FDA’s Manufacturer and User Facility Device Experience (MAUDE) database […]
Cardiology Business June 19, 2025
Lilly Buys Verve, Bringing Gene Editing Mainstream June 19, 2025
Gene editing for heart disease just got a major boost as Eli Lilly acquired Verve Therapeutics and its one-dose cholesterol drugs for up to $1.3B, marking a new path for Verve’s therapies to go mainstream. Part of the acquisition likely stems from Verve’s recent impressive trial results for its PCSK9-blocking treatment, VERVE-102, which lowered LDL-C […]
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Cardiac Imaging June 19, 2025
New AI-driven Tool Aids in Mitral Valve Assessment June 19, 2025
By: Jimmy Su, Ph.D. Principal Scientist, Cardiovascular Ultrasound, Philips A new tool, Automated 3D Color Flow Quantification (3D Auto CFQ), removes the reliance on assumptions when quantifying mitral regurgitation and replaces it with a reliable and robust, AI-driven method that delivers precise measurement of mitral valve regurgitant volume (RVol) regardless of orifice shape and size. Eliminating assumptions: Quantification […]
Cardiac Imaging June 16, 2025
Beyond Hardware: Is AI the Answer to Making Cardiac Imaging More Accessible? June 16, 2025
Sponsored by Philips Healthcare Cardiac imaging has traditionally improved through hardware advances, enabling the speed needed for high-quality images. However, hardware is rapidly reaching its physical limitations in suppressing cardiac motion and represents a large financial investment. Today, software and AI are driving the next leap in cardiac image quality and motion control – offering […]
Cardiology Pharmaceuticals June 16, 2025
No Need to Discontinue Abelacimab Pre-Procedure June 16, 2025
A new analysis of AZALEA-TIMI 71 suggests Anthos Therapeutics’ abelacimab is capable of reducing major bleeding in patients with AFib undergoing invasive procedures. The sub-analysis examined a total of 920 procedures across 441 patients taking either abelacimab or rivaroxaban, with approximately 1-in-3 patients undergoing an invasive procedure over a median follow-up of 2.1 years. Researchers […]
Cardiology Pharmaceuticals June 12, 2025
Pharmacologic Preconditioning to Improve Outcomes in Patients Undergoing Cardiac Surgery June 12, 2025
The majority of patients undergoing cardiac surgery, especially those on cardiopulmonary bypass (CPB), experience post-operative complications such as new-onset atrial fibrillation (POAF) and acute kidney injury (AKI), largely driven by oxidative stress and inflammation. Several approaches have been explored to reduce complications following cardiac surgery, however, a clinically meaningful impact has yet to be realized. […]
Cardiology Pharmaceuticals June 12, 2025
FDA Approves a New BP Triple Polypill June 12, 2025
Bringing a more effective BP therapy to the U.S. market, the FDA approved George Medicines’ triple therapy polypill called Widaplik for patients with hypertension, making it the first of its kind to go to market in the U.S. Widaplik’s approval stems from two studies, including one comparing the polypill against placebo as an initial treatment […]
Surgeries & Interventions June 9, 2025
Contrast Use During PCI on the Decline June 9, 2025
New ACC registry data suggests interventional cardiologists are using less contrast for PCI procedures in the cath lab which helps reduce post-PCI acute kidney injury risks, but a deeper look tells us there’s still room for improvement. Searching for cath lab trends, researchers examined 3.12M unique PCI procedures performed by 3.6k physicians from 2018 to […]
Cardiology Pharmaceuticals June 5, 2025
Regeneron & Hansoh’s GLP-1 Deal June 5, 2025
Just a few weeks after the full results of SURMOUNT-5 crowned Eli Lilly’s GLP-1/GIP tirzepatide king of the GLP-1s, Regeneron announced it will pay Hansoh Pharma $80M upfront and up to $1.93B in milestone payments for its Phase 3-stage GLP-1/GIP drug, HS-20094. It’s the early testing edge that has Regeneron excited about Hansoh’s HS-20094, since […]
Cardiology Pharmaceuticals June 2, 2025
Deeper Answers from the ABYSS Trial June 2, 2025
Diving deeper into the ABYSS trial, a new sub-analysis suggests that patients with MI and preserved LVEF who stop taking their beta-blockers experience significant rises in heart rate and BP, potentially increasing their risk of adverse events. Now ABYSS’ new sub-analysis gives insights as to why beta-blockers help reduce adverse outcomes post-MI by examining the […]
Cardiology Business May 29, 2025
Boston Scientific Bows Out on TAVR May 29, 2025
Marking its departure from the TAVR market, Boston Scientific officially discontinued sales of its Acurate neo2 and Acurate Prime TAVR systems and will no longer seek approval from the FDA or other regulatory agencies. While there’s no one reason to blame for Boston’s decision, it’s likely the recent three way clinical comparison trial presented at […]
Surgeries & Interventions May 22, 2025
Navitor Versus Sapien 3 Ultra: Different in the Details May 22, 2025
One year data from the NAVULTRA study published in JACC suggests that Edwards’ Sapien 3 Ultra and Abbott’s Navitor intra-annular TAVR valves have similar short-term clinical outcomes, with a few key differences. The NAVULTRA study explored data from 4k TAVR patients who received either Navitor or Sapien 3 Ultra and found that all-cause mortality was […]
Cardiology Pharmaceuticals May 19, 2025
Wegovy Rapidly Lowers MACE Risk May 19, 2025
Getting us closer to understanding GLP-1s’ heart benefits, a post hoc analysis of the SELECT trial suggests that Novo Nordisk’s Wegovy (semaglutide) significantly reduces a patient’s MACE risk in just three months of treatment. Researchers analyzed the SELECT trial data by looking at CV events in the first three to six months following semaglutide treatment […]
Cardiology Pharmaceuticals May 15, 2025
Tirzepatide Beats Semaglutide in Weight Loss May 15, 2025
Has a king of the GLP-1s finally been crowned? Full results from the SURMOUNT-5 trial published in NEJM seem to suggest that Eli Lilly’s tirzepatide (Zepbound/Mounjarno) could be better than Novo Nordisk’s semaglutide (Wegovy/Ozempic). Weighing the weight loss benefits of each drug, SURMOUNT-5’s researchers randomized 751 obese patients without T2D to receive either tirzepatide (10mg/15mg) […]
Cardiology Testing May 12, 2025
Predicting ASCVD With Calprotectin May 12, 2025
Knowing which biomarkers to look for is critical to diagnosing and preventing ASCVD, and a new JAMA study suggests calprotectin could be the key to catching ASCVD early. So how does calprotectin predict ASCVD? To answer this, researchers measured calprotectin levels in plasma collected from 2.4k participants during Phase 2 of the Dallas Heart Study […]
Cardiology Pharmaceuticals May 8, 2025
Obicetrapib Puts on a Show May 8, 2025
Results from NewAmsterdam Pharma’s Phase 3 BROADWAY and TANDEM trials suggest that obicetrapib could be an effective LDL-C lowering treatment, both on its own or combined with another drug. TANDEM examined the effects of a fixed-dose obicetrapib/ezetimibe combination therapy and found… BROADWAY put on a one-man show for obicetrapib as a monotherapy to help confirm […]
Cardiology Pharmaceuticals May 8, 2025
Marea Makes Progress on MAR001 May 8, 2025
Marea Therapeutics presented positive data from the Phase 2a clinical trial of its fat-targeting monoclonal antibody, MAR001, that could help address lipid and metabolic drivers of ASCVD. To assess MAR001’s impact on remnant cholesterol and triglycerides, researchers randomized 55 patients with hypertriglyceridemia to one of three doses (150, 300, and 450mg) or placebo and found… […]
Surgeries & Interventions May 5, 2025
FDA Approves TAVR for Asymptomatic AS May 5, 2025
TAVR will officially be an option for asymptomatic patients with severe aortic stenosis following the FDA’s approval of Edwards Lifesciences’ SAPIEN 3 platform for the patient group. EARLY TAVR was the first RCT designed to evaluate TAVR compared to watchful waiting for patients with asymptomatic severe AS. These results helped inform the FDA’s decision, but […]
Cardiology May 1, 2025
Cardiac Wire’s Top Six of HRS 2025 May 1, 2025
Heart Rhythm Society and sunny San Diego brought together the biggest HRS in years, with everything from custom presentation theaters to exciting afterparties. We hope everyone who attended HRS 2025 had as much fun as we did, and we hope all of you enjoy these top-six takeaways from electrophysiology’s biggest weekend of the year. HRS […]
Atrial Fibrillation April 28, 2025
GLP-1s Add AFib To Their Benefits List April 28, 2025
It seems like every week we’re discovering a new GLP-1 cardiac benefit, with the TRANSFORM-AF study now suggesting the drug could help reduce AFib burden. Examining the effects of GLP-1s on AFib, researchers examined 2.5k patients from 170 Veterans Affairs sites across the U.S. and found that AFib patients with obesity who were treated with […]
